Everysingle ship in the ZST aim at whatever spot they like and shoot randomly. It not like they don't have enough dakka to destroy the Omniverse. They have more than enough to destroy it a hundred time.
YUUSHA R*PE Edit
Just call a Yuusha, give him five minute .... and a new Omniverse need to create.
NUKE THE HELL OUTA THEM Edit
Ya know ... they built Little Boy Hiroshima and Fat Man Nagasaki for a reason.
General Order 731 Edit
Basically throw a bomb that will inflicted all the disea imaginable AT THE SAME TIME. On an Omniversal Scale at whatever place that they feel fit. Grab some popcorn and watch the sh*tstorm.